MSU, the adjuvans of dying cells activates the NALP3 inflammasome by sodium overload
نویسندگان
چکیده
منابع مشابه
Sodium overload and water influx activate the NALP3 inflammasome.
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of the proinflammatory cytokine IL-1β. However, the mechanism of [K(+)](i) lowering after phagocytosis of monosodium urate crystals is still elusive. Here, we propose that endosomes containing monosodium urate crystals fuse with acidic lysosomes. The low pH in the phagolysosome ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2011
ISSN: 0003-4967
DOI: 10.1136/ard.2010.149096.20